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Opaganib - RedHill Biopharma

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Drug Profile

Opaganib - RedHill Biopharma

Alternative Names: ABC-294640; YELIVA

Latest Information Update: 30 Apr 2026

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At a glance

  • Originator Apogee Biotechnology Corporation
  • Developer Apogee Biotechnology Corporation; Medical University of South Carolina; RedHill Biopharma; University of Louisville
  • Class Adamantanes; Amides; Anti-inflammatories; Antihypoglycaemics; Antineoplastics; Antirheumatics; Antithrombotics; Antivirals; Chlorobenzenes; Obesity therapies; Pyridines; Small molecules
  • Mechanism of Action Sphingosine kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Neuroblastoma; Cholangiocarcinoma
  • New Molecular Entity Yes
  • Available For Licensing Yes - Cancer; Inflammation

Highest Development Phases

  • Phase II/III COVID-19 pneumonia
  • Phase II Cholangiocarcinoma; Prostate cancer
  • Preclinical Ebola virus infections; Influenza A virus infections; Neuroblastoma; Obesity; Radiation injuries; Triple negative breast cancer; Type 2 diabetes mellitus
  • Suspended Liver cancer
  • No development reported Acute radiation syndrome; Cancer; COVID 2019 infections; Inflammatory bowel diseases; Osteoarthritis; Renal fibrosis; Rheumatoid arthritis; SARS-CoV-2 acute respiratory disease; Solid tumours
  • Discontinued Multiple myeloma

Most Recent Events

  • 22 Apr 2026 Preclinical trials in Neuroblastoma in USA (PO)
  • 22 Apr 2026 Preclinical trials in Triple-negative-breast-cancer in USA (PO)
  • 22 Apr 2026 Pharmacodynamics data from a preclinical trial in neuroblastoma and triple-negative breast cancer released by RedHill Biopharma

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