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Opaganib - RedHill Biopharma

Drug Profile

Opaganib - RedHill Biopharma

Alternative Names: ABC-294640; YELIVA

Latest Information Update: 07 Jun 2024

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At a glance

  • Originator Apogee Biotechnology Corporation
  • Developer Apogee Biotechnology Corporation; Medical University of South Carolina; RedHill Biopharma; University of Louisville
  • Class Adamantanes; Amides; Anti-inflammatories; Antineoplastics; Antirheumatics; Antithrombotics; Antivirals; Chlorobenzenes; Pyridines; Small molecules
  • Mechanism of Action Sphingosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cholangiocarcinoma
  • New Molecular Entity Yes
  • Available For Licensing Yes - Cancer; Inflammation

Highest Development Phases

  • Phase II/III COVID-19 pneumonia
  • Phase II Cholangiocarcinoma; Prostate cancer
  • Preclinical Acute radiation syndrome; COVID 2019 infections; Ebola virus infections; Influenza A virus infections; Radiation injuries; Renal fibrosis; SARS-CoV-2 acute respiratory disease
  • Suspended Liver cancer
  • No development reported Cancer; Inflammatory bowel diseases; Osteoarthritis; Rheumatoid arthritis; Solid tumours
  • Discontinued Multiple myeloma

Most Recent Events

  • 24 May 2024 RedHill Biopharma receives a new Chinese patent Notice of Allowance from the Chinese National Intellectual Property Administration (CNIPA) providing protection for opaganib and its potential use with a range of approved and in-development immune checkpoint inhibitors
  • 06 May 2024 RedHill Biopharma announces intention to submit IND application to the US FDA for a phase I trial of opaganib as chemoradiotherapy
  • 06 May 2024 RedHill Biopharma plans a phase I trial of opaganib as chemoradiotherapy
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