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Opaganib - RedHill Biopharma

Drug Profile

Opaganib - RedHill Biopharma

Alternative Names: ABC-294640; YELIVA

Latest Information Update: 23 Feb 2024

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At a glance

  • Originator Apogee Biotechnology Corporation
  • Developer Apogee Biotechnology Corporation; Medical University of South Carolina; RedHill Biopharma; University of Louisville
  • Class Adamantanes; Amides; Anti-inflammatories; Antineoplastics; Antirheumatics; Antithrombotics; Antivirals; Chlorobenzenes; Pyridines; Small molecules
  • Mechanism of Action Sphingosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cholangiocarcinoma
  • New Molecular Entity Yes
  • Available For Licensing Yes - Cancer; Inflammation

Highest Development Phases

  • Phase II/III COVID-19 pneumonia
  • Phase II Cholangiocarcinoma; Prostate cancer
  • Preclinical Acute radiation syndrome; COVID 2019 infections; Ebola virus infections; Influenza A virus infections; Radiation injuries; Renal fibrosis; SARS-CoV-2 acute respiratory disease
  • Suspended Liver cancer
  • No development reported Cancer; Inflammatory bowel diseases; Osteoarthritis; Rheumatoid arthritis; Solid tumours
  • Discontinued Multiple myeloma

Most Recent Events

  • 20 Feb 2024 Pharmacodynamic data from the preclinical study in acute radiation syndrome released by RedHill Biopharma
  • 20 Dec 2023 Pharmacodynamics data from a preclinical study in Ebola virus infections released by RedHill Biopharma
  • 03 Oct 2023 Preclinical trials in Ebola virus infections in USA prior to October 2023 (PO)
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