Tivozanib - Kyowa Hakko Kirin/AVEO Oncology

Drug Profile

Tivozanib - Kyowa Hakko Kirin/AVEO Oncology

Alternative Names: ASP 4130; AV-951; AVE-951; Fotivda; Kil8951; KRN-951; Tivopath; Tivozanib hydrochloride monohydrate

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Kirin Brewery
  • Developer Astellas Pharma; AVEO Oncology; EUSA Pharma; Institute Gustave-Roussy; Kyowa Hakko Kirin; Northwestern University; Pharmstandard
  • Class Antineoplastics; Isoxazoles; Quinolines; Small molecules; Urea compounds
  • Mechanism of Action Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cell carcinoma
  • New Molecular Entity Yes
  • Available For Licensing Yes - Age-related macular degeneration; Renal cell carcinoma

Highest Development Phases

  • Marketed Renal cell carcinoma
  • Phase II Soft tissue sarcoma
  • Phase I/II Liver cancer
  • Preclinical Age-related macular degeneration
  • Suspended Breast cancer; Colorectal cancer; Fallopian tube cancer; Gastrointestinal cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer
  • No development reported Solid tumours

Most Recent Events

  • 28 Aug 2018 No recent reports of development identified for phase-I development in Solid-tumours in Japan (PO, Capsule)
  • 11 Jul 2018 Tivozanib - Kyowa Hakko Kirin/AVEO Oncology is available for licensing for Age-related macular degeneration in North America, European Union as of 11 Jul 2018. http://www.aveooncology.com (AVEO Oncology pipeline, July 2018)
  • 11 Jul 2018 Preclinical trials in Age-related macular degeneration in USA (Ophthalmic) (AVEO Oncology pipeline, July 2018)
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