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Azacitidine - Pfizer

Drug Profile

Azacitidine - Pfizer

Alternative Names: 5-azacytidine; Aza-C; Azacytidine; CC-486; Ladakamycin; NS-17; NSC-102816; U-18496; VIDAZA; Vidaza

Latest Information Update: 07 Jan 2019

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At a glance

  • Originator Pharmacia Corporation
  • Developer Australasian Leukaemia & Lymphoma Group; Celgene Corporation; Columbia University; H. Lee Moffitt Cancer Center and Research Institute; Karolinska University Hospital; Kirby Institute for infection and immunity in society; Medical University of South Carolina; Nippon Shinyaku; Pfizer; University Hospital Regensburg; University of Bologna; University of Colorado at Denver; University of Kansas Medical Center; University of Leipzig; University of Texas M. D. Anderson Cancer Center; University of Utah; Washington University School of Medicine; Weill Cornell Medical College
  • Class Antineoplastics; Aza compounds; Pyrimidine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action Antimetabolites; DNA methylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Phase II Breast cancer; Graft-versus-host disease; Leukaemia; Nasopharyngeal cancer; Non-small cell lung cancer; Peripheral T-cell lymphoma
  • Phase I/II Colorectal cancer; Diffuse large B cell lymphoma; Renal cancer; Solid tumours
  • Phase I Lymphoma
  • No development reported Multiple myeloma

Most Recent Events

  • 28 Dec 2018 Celgene completes a phase II trial in Solid tumours and Haematological disorders in France (EudraCT2016-000069-22)
  • 18 Dec 2018 Phase-I clinical trials is ongoing in Lymphoma (Combination therapy, First-line therapy) in USA (PO) (NCT02343536)
  • 01 Dec 2018 Efficay and adverse events data from a phase-I trial in Lymphoma presented at the 60th Annual Meeting and Exposition of the American Society of Hematology (ASH-2018)
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