AMG 0101
Alternative Names: AMG0101; AMG0102; AMG0103; AMS-001; MP 40; MP 41; MP 42; NDON; NF-kappa-B decoy oligo; NF-kappa-B decoy oligonucleotide; NF-kappa-B-Decoy-AnGes-MG; NF-kappa-B-transcription-factor-Decoy-AnGes; NF-kappaB decoy; NF-kB decoy oligo; NF-kD-transcription-factor-Decoy-AnGes; NF-κB decoy oligo DNA; Nuclear-factor-kappa-B-Decoy-AnGes; S-414114; SI-3104Latest Information Update: 28 Dec 2023
At a glance
- Originator AnGes MG; Osaka University
- Developer AnGes; Hosokawa Micron Corporation; Medikit; Morishita Jintan; Nippon Zoki; Osaka University; Shionogi
- Class Analgesics; Anti-inflammatories; Antipsoriatics; Antirheumatics; Oligonucleotides; Skin disorder therapies
- Mechanism of Action Genetic transcription modulators; NF-kappa B inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase III Atopic dermatitis
- Phase II Back pain
- Discontinued Inflammatory bowel diseases; Intervertebral disc degeneration; Musculoskeletal disorders; Pain; Periodontal disorders; Psoriasis; Respiratory tract disorders; Spondylosis; Vascular restenosis
Most Recent Events
- 28 Dec 2023 No recent reports of development identified for phase-I development in Back-pain in USA (Intra-articular, Injection)
- 18 Oct 2023 Phase-II clinical trials in Back pain in Japan (Intra-articular)
- 21 Mar 2023 AnGes in collaboration with Shionogi plans a phase III trial for Chronic discogenic low back pain in Japan