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Research programme: short interfering RNA-based therapeutics - Silence Therapeutics

Drug Profile

Research programme: short interfering RNA-based therapeutics - Silence Therapeutics

Alternative Names: GalNAc-siRNA - Silence Therapeutics; ICS-283; Research programme: RNAi-based therapeutics -Intradigm/Qiagen; SLN-124

Latest Information Update: 27 Mar 2018

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At a glance

  • Originator Intradigm Corporation
  • Developer Intradigm Corporation; OPKO Health; Silence Therapeutics
  • Class Small interfering RNA
  • Mechanism of Action RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Iron overload
  • Research Acromegaly; Alcoholism; Cardiovascular disorders; Metabolic disorders
  • Discontinued Age-related macular degeneration; Cancer; Coronavirus infections; Diabetic retinopathy

Most Recent Events

  • 26 Mar 2018 Preclinical trials in Iron overload in United Kingdom (Parenteral) before March 2018 (Silence Therapeutics pipeline, March 2018)
  • 06 Mar 2018 Silence Therapeutics plans to initiate a clinical trial of SLN 124 by the end of 2018
  • 17 Jan 2018 Silence Therapeutics has patent protection for siRNA chemical modifications in European union
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