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TPI 287

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Drug Profile

TPI 287

Alternative Names: ARC-100; NBT 287; TPI-287

Latest Information Update: 18 Dec 2024

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At a glance

  • Originator Tapestry Pharmaceuticals
  • Developer Archer Biosciences; Cortice Biosciences; H. Lee Moffitt Cancer Center and Research Institute; Tapestry Pharmaceuticals; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center; Van Andel Research Institute
  • Class Antidementias; Antineoplastics; Small molecules; Taxanes
  • Mechanism of Action Microtubule protein modulators; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Progressive supranuclear palsy
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Glioblastoma
  • Phase I/II Malignant melanoma
  • No development reported Alzheimer's disease; Cancer; Corticobasal degeneration; Medulloblastoma; Neuroblastoma; Non-small cell lung cancer; Progressive supranuclear palsy
  • Discontinued Pancreatic cancer; Prostate cancer

Most Recent Events

  • 30 Jul 2024 TPI 287 licensed to CNS Pharmaceuticals in the US, Mexico, Japan and Canada
  • 30 Jul 2024 CNS Pharmaceuticals plans a registrational trial for Glioblastoma in 2025
  • 28 Nov 2023 No recent reports of development identified for phase-I development in Alzheimer's-disease in USA (IV, Infusion)

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