Drug Profile


Alternative Names: ACT-GRO-777; AGRO-100; AS1411

Latest Information Update: 16 Jul 2016

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At a glance

  • Originator University of Alabama; University of Louisville
  • Developer Advanced Cancer Therapeutics; James Graham Brown Cancer Center
  • Class Antineoplastics; Nucleotide aptamers; Oligodeoxyribonucleotides
  • Mechanism of Action Apoptosis stimulants; Nucleolin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Acute myeloid leukaemia; Renal cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cancer
  • No development reported Neuroblastoma

Most Recent Events

  • 16 Jul 2016 No recent reports of development identified for preclinical development in Neuroblastoma in USA (IV)
  • 03 May 2011 Preclinical trials in Neuroblastoma in USA (IV)
  • 28 Apr 2011 Advanced Cancer Therapeutics acquires ACT GRO 777 from Antisoma
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