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Selumetinib - AstraZeneca

Drug Profile

Selumetinib - AstraZeneca

Alternative Names: AR 00142886; AR 142886 X; ARRY-142886; ARRY-886; AZD 142886; AZD-6244; AZD-6244 hydrogen sulfate; AZD6244 Hyd-Sulfate; AZD6244 hydrogen sulphate; KOSELUGO; MK 5618; NSC-748727; Selumetinib hydrogen sulfate

Latest Information Update: 02 Oct 2021

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At a glance

  • Originator Array BioPharma
  • Developer Array BioPharma; AstraZeneca; Cancer Research UK; Merck & Co; Merck Sharp & Dohme Corp.; National Cancer Institute (USA); University of Cambridge; University of Chicago
  • Class Amides; Amines; Antineoplastics; Benzimidazoles; Halogenated hydrocarbons; Small molecules
  • Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer; Neurofibromatosis 1; Uveal melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Neurofibromatosis 1
  • Phase III Glioma
  • Phase II Biliary cancer; Colorectal cancer; Gastric cancer; Histiocytosis; Neurofibromatosis 2; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Solid tumours; Uveal melanoma
  • Phase I/II Kaposi's sarcoma; Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase I Myelodysplastic syndromes; Myelofibrosis
  • No development reported Pancreatic cancer
  • Discontinued Acute myeloid leukaemia; Liver cancer; Malignant melanoma; Multiple myeloma; Thyroid cancer

Most Recent Events

  • 01 Oct 2021 Biomarkers information updated
  • 20 Sep 2021 Phase-III clinical trials in Neurofibromatosis 1 in Australia (PO) (NCT04924608) (EudraCT2020-005607-39)
  • 22 Jun 2021 Registered for Neurofibromatosis 1 (In adolescents, In children, Monotherapy) in European Union, European Union, Norway, Liechtenstein, Iceland (PO, Capsule)
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