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Brincidofovir - Chimerix

Drug Profile

Brincidofovir - Chimerix

Alternative Names: BCV; Cidofovir hexadecyloxypropyl ester; Cidofovir PIM conjugate; CMX-001; HDP-CDV; HDP-cidofovir; Hexadecyl-oxypropyl cidofovir - Chimerix

Latest Information Update: 18 Nov 2018

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At a glance

  • Originator University of California, San Diego
  • Developer Centers for Disease Control and Prevention; Chimerix; National Institutes of Health (USA); University of Oxford
  • Class Antivirals; Phosphonic acids; Pyrimidinones; Small molecules
  • Mechanism of Action DNA-directed DNA polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Smallpox; Cytomegalovirus infections; Adenovirus infections
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Adenovirus infections; Cytomegalovirus infections; Smallpox
  • Phase II/III Viral infections
  • Research Monkeypox
  • No development reported Human polyomavirus infections
  • Discontinued Ebola virus infections

Most Recent Events

  • 08 Nov 2018 Phase-II clinical trials in Adenovirus infections (In adults, In the elderly) in Spain, USA (IV) (EudraCT2017-003984-37)
  • 08 Nov 2018 Chimerix announces intention to submit MAA to EMA for oral brincidofovir for Smallpox following the completion of the rabbit and mouse efficacy studies in 2019
  • 08 Nov 2018 Pharmacokinetics data from a phase I trial in Viral infections released by Chimerix
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