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Berubicin - CNS Pharmaceuticals

Drug Profile

Berubicin - CNS Pharmaceuticals

Alternative Names: Berubicin hydrochloride; Reata 744; RTA 744; WP744

Latest Information Update: 09 Apr 2024

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At a glance

  • Originator University of Texas M. D. Anderson Cancer Center
  • Developer CNS Pharmaceuticals; WPD Pharmaceuticals
  • Class Amines; Anthracyclines; Antineoplastics; Carboxylic acids; Ethers; Pyrans; Small molecules
  • Mechanism of Action Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Glioblastoma
  • Phase I/II Lymphoma
  • Research Breast cancer; Lung cancer
  • No development reported Ovarian cancer; Pancreatic cancer
  • Discontinued Brain metastases; Neoplastic meningitis

Most Recent Events

  • 05 Apr 2024 WPD Pharmaceuticals terminates a phase I/II trial for Glioblastoma (Second-line therapy or greater) in Poland (IV, Infusion) due to progress made by their licensor, CNS Pharmaceuticals, in the potentially pivotal CNS-201 trial (NCT04915404)
  • 30 Dec 2023 WPD Pharmaceuticals withdraws a phase I trial in Glioma (In children, In adolescents, Second-line therapy or greater), prior to enrolment due to business decision (IV) (NCT05082493)
  • 28 Dec 2023 No recent reports of development identified for preclinical development in Lymphoma in USA (IV)
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