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Drug Profile



Latest Information Update: 28 Oct 2018

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At a glance

  • Originator Gene Signal
  • Class Antisense oligonucleotides; Eye disorder therapies; Skin disorder therapies
  • Mechanism of Action Insulin receptor substrate protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glaucoma; Keratoplasty rejection; Central retinal vein occlusion; Retinopathy of prematurity
  • New Molecular Entity Yes
  • Available For Licensing Yes - Age-related macular degeneration; Diabetic retinopathy; Glaucoma; Keratoplasty rejection; Psoriasis; Retinopathy of prematurity; Rosacea

Highest Development Phases

  • Phase III Keratoplasty rejection
  • Phase II Central retinal vein occlusion; Psoriasis
  • Preclinical Bladder cancer
  • No development reported Diabetic retinopathy; Glaucoma; Retinopathy of prematurity; Rosacea; Wet age-related macular degeneration
  • Discontinued Age-related macular degeneration

Most Recent Events

  • 28 Oct 2018 No recent reports of development identified for phase-I development in Wet age-related macular degeneration in France (Parenteral)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Diabetic-retinopathy in France (Parenteral)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Glaucoma in European Union (Topical, Ointment)
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