Apremilast - Celgene

Drug Profile

Apremilast - Celgene

Alternative Names: CC-10004; CC-1004; OTEZLA; Otezla

Latest Information Update: 15 Oct 2018

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At a glance

  • Originator Celgene Corporation
  • Developer Baylor Research Institute; Celgene Corporation; Erasmus MC
  • Class Acetamides; Anti-inflammatories; Antineoplastics; Antipsoriatics; Isoindoles; Phthalimides; Skin disorder therapies; Small molecules; Sulfones
  • Mechanism of Action Interleukin 23 inhibitors; Interleukin-10 expression stimulants; Tumour necrosis factor alpha inhibitors; Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ulcerative colitis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Plaque psoriasis; Psoriatic arthritis
  • Preregistration Behcet's syndrome
  • Phase III Ankylosing spondylitis
  • Phase II Atopic dermatitis; Eczema; Hidradenitis suppurativa; Ulcerative colitis
  • No development reported Rheumatoid arthritis
  • Discontinued Asthma; Cancer; Crohn's disease

Most Recent Events

  • 08 Oct 2018 Adverse events and efficacy data from a phase III trial in Plaque psoriasis released by Celgene
  • 24 Jun 2018 Biomarkers information updated
  • 13 Jun 2018 Efficacy, adverse events and pharmacokinetics data from the phase III RELIEF trial in Behcet's disease presented at the 19th Annual Congress of the European League Against Rheumatism (EULAR-2018)
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