Drug Profile

Rose bengal sodium - Provectus Biopharmaceuticals

Alternative Names: PH-10; Provecta; PV-10; Rose bengal; Rose bengal disodium; Rose bengal sodium I 125; Rose bengal sodium I 131; Xantryl

Latest Information Update: 06 Oct 2025

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At a glance

Originator Photogen Technologies Inc.
Developer Pediatric Oncology Experimental Therapeutics Investigators Consortium; Provectus Biopharmaceuticals; University of Calgary
Class Anti-infectives; Anti-inflammatories; Antiacnes; Antibacterials; Antineoplastics; Antipsoriatics; Antivirals; Benzoates; Eye disorder therapies; Fluoresceins; Halogenated hydrocarbons; Skin disorder therapies; Small molecules; Xanthenes
Mechanism of Action Cell death stimulants; Cell membrane modulators; Dendritic cell stimulants; Immunostimulants; Interferon modulators; Interleukin 17 modulators; Interleukin-22 modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Uveal melanoma; Liver cancer; Neuroblastoma; Malignant melanoma
New Molecular Entity Yes

Phase III Malignant melanoma
Phase II Atopic dermatitis; Psoriasis
Preclinical Bladder cancer; Squamous cell cancer; Wounds
No development reported Actinic keratosis; COVID 2019 infections; Ewing's sarcoma; Gram-negative infections; Gram-positive infections; Haematological malignancies; Infectious keratitis; Liver cancer; Liver metastases; Lymphoid leukaemia; Myeloid leukaemia; Neuroendocrine tumours; Osteosarcoma; Pancreatic cancer; Rhabdomyosarcoma; Solid tumours
Discontinued Acne vulgaris; Breast cancer

29 Sep 2025 Preclinical trials in Bladder cancer in USA (Intravesicular)
29 Sep 2025 Preclinical trials in Bladder cancer in USA (PO)
28 Jun 2025 No recent reports of development identified for preclinical development in COVID-2019-infections in USA (PO)

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