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AV 101

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Drug Profile

AV 101

Alternative Names: 4-Chlorokynurenine - VistaGen; 4-CL-KYN; 7-CL-KYNA; AV-101; L-4-chlorokynurenine; L-4-CL-KYN

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator Artemis Neuroscience
  • Developer Baylor College of Medicine; Jade Biosciences; National Institute of Mental Health; VistaGen Therapeutics
  • Class Analgesics; Antidepressants; Antiepileptic drugs; Antihypertensives; Antiparkinsonians; Behavioural disorder therapies; Butyric acids; Neuroprotectants; Small molecules
  • Mechanism of Action Kynurenine modulators; NMDA receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Hypertension
  • Phase II Major depressive disorder
  • No development reported Epilepsy; Huntington's disease; Neurological disorders; Neuropathic pain; Parkinson's disease; Psychiatric disorders; Suicidal ideation

Most Recent Events

  • 28 Jan 2026 No recent reports of development identified for phase-I development in Neurological-disorders(In volunteers) in USA (PO)
  • 28 Jan 2026 No recent reports of development identified for phase-I development in Neuropathic-pain(In volunteers) in USA (PO)
  • 28 Apr 2025 Aerovate Therapeutics has merged with Jade Biosciences to form Jade Biosciences

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