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AV 101

Drug Profile

AV 101

Alternative Names: 4-Chlorokynurenine - VistaGen; 4-CL-KYN; 7-CL-KYNA; AV101; L-4-chlorokynurenine; L-4-CL-KYN

Latest Information Update: 06 Nov 2019

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At a glance

  • Originator Artemis Neuroscience
  • Developer Baylor College of Medicine; National Institute of Mental Health; VistaGen Therapeutics
  • Class Analgesics; Antidepressants; Antiepileptic drugs; Antiparkinsonians; Behavioural disorder therapies; Neuroprotectants; Small molecules
  • Mechanism of Action NMDA receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Major depressive disorder
  • Phase I Neuropathic pain; Suicidal ideation
  • Preclinical Psychiatric disorders
  • No development reported Epilepsy; Huntington's disease; Parkinson's disease

Most Recent Events

  • 01 Nov 2019 VistaGen Therapeutics plans a phase II trial in Drug-induced dyskinesia and Parkinson's disease in July 2020 (PO) (NCT04147949)
  • 28 Oct 2019 VistaGen Therapeutics expands patent protection for AV 101 in Europe
  • 01 Oct 2019 VistaGen completes the phase II ELEVATE trial in Major depressive disorder (Adjunctive treatment, Treatment-experienced) in USA (NCT03078322)
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