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AV 101

Drug Profile

AV 101

Alternative Names: 4-Chlorokynurenine - VistaGen; 4-CL-KYN; 7-CL-KYNA; AV-101; L-4-chlorokynurenine; L-4-CL-KYN

Latest Information Update: 28 Mar 2022

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At a glance

  • Originator Artemis Neuroscience
  • Developer Baylor College of Medicine; National Institute of Mental Health; VistaGen Therapeutics
  • Class Analgesics; Antidepressants; Antiepileptic drugs; Antiparkinsonians; Behavioural disorder therapies; Butyric acids; Neuroprotectants; Small molecules
  • Mechanism of Action Kynurenine modulators; NMDA receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Major depressive disorder
  • Phase I Neurological disorders
  • Preclinical Psychiatric disorders
  • No development reported Epilepsy; Huntington's disease; Neuropathic pain; Parkinson's disease; Suicidal ideation

Most Recent Events

  • 28 Mar 2022 No recent reports of development identified for phase-I development in Suicidal-ideation(In volunteers) in USA (PO)
  • 17 Sep 2021 Aerovate Therapeutics plans a phase IIb/III trial for Pulmonary arterial hypertension (PO) in 2021
  • 28 Aug 2021 No recent reports of development identified for phase-I development in Epilepsy in USA (PO)
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