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AV 101

Drug Profile

AV 101

Alternative Names: 4-Chlorokynurenine - VistaGen; 4-CL-KYN; 7-CL-KYNA; AV-101; L-4-chlorokynurenine; L-4-CL-KYN

Latest Information Update: 01 Jan 2024

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At a glance

  • Originator Artemis Neuroscience
  • Developer Aerovate Therapeutics; Baylor College of Medicine; National Institute of Mental Health; VistaGen Therapeutics
  • Class Analgesics; Antidepressants; Antiepileptic drugs; Antihypertensives; Antiparkinsonians; Behavioural disorder therapies; Butyric acids; Neuroprotectants; Small molecules
  • Mechanism of Action Kynurenine modulators; NMDA receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Hypertension
  • Phase II Major depressive disorder
  • Phase I Neurological disorders; Neuropathic pain
  • No development reported Epilepsy; Huntington's disease; Parkinson's disease; Psychiatric disorders; Suicidal ideation

Most Recent Events

  • 27 Dec 2023 Phase I development is ongoing in Neuropathic pain (healthy volunteers) in USA (Vistagen pipeline, December 2023)
  • 27 Dec 2023 AV 101 is available for licensing as of 27 Dec 2023. http://sntpseditorial/adis2000www/script/citation/citationmain.asp?Adnm=9406756
  • 27 Dec 2023 VistaGen Therapeutics a Notice of Intention to Grant a European patent covering the use of AV 101 by the European Patent Office
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