AV 101
Alternative Names: 4-Chlorokynurenine - VistaGen; 4-CL-KYN; 7-CL-KYNA; AV-101; L-4-chlorokynurenine; L-4-CL-KYNLatest Information Update: 01 Jan 2024
At a glance
- Originator Artemis Neuroscience
- Developer Aerovate Therapeutics; Baylor College of Medicine; National Institute of Mental Health; VistaGen Therapeutics
- Class Analgesics; Antidepressants; Antiepileptic drugs; Antihypertensives; Antiparkinsonians; Behavioural disorder therapies; Butyric acids; Neuroprotectants; Small molecules
- Mechanism of Action Kynurenine modulators; NMDA receptor antagonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
- Available For Licensing Yes
Highest Development Phases
- Phase III Hypertension
- Phase II Major depressive disorder
- Phase I Neurological disorders; Neuropathic pain
- No development reported Epilepsy; Huntington's disease; Parkinson's disease; Psychiatric disorders; Suicidal ideation
Most Recent Events
- 27 Dec 2023 Phase I development is ongoing in Neuropathic pain (healthy volunteers) in USA (Vistagen pipeline, December 2023)
- 27 Dec 2023 AV 101 is available for licensing as of 27 Dec 2023. http://sntpseditorial/adis2000www/script/citation/citationmain.asp?Adnm=9406756
- 27 Dec 2023 VistaGen Therapeutics a Notice of Intention to Grant a European patent covering the use of AV 101 by the European Patent Office