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AS 1409

Drug Profile

AS 1409

Alternative Names: Antibody-cytokine fusion drug (AS1409); AS-1409; BC1-IL-12; hBC1-hIL-12; huBC1/IL-12 fusion protein; huBC1/IL12 fusion drug; Tumour-targeting antibody BC1/IL-12 fusion drug

Latest Information Update: 19 Jul 2012

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At a glance

  • Originator Antisoma; EMD Lexigen
  • Developer Antisoma
  • Class Antibodies; Antineoplastics; Interleukins; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Interferon gamma stimulants; Natural killer cell stimulants; Th1 cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cancer; Malignant melanoma; Renal cancer

Most Recent Events

  • 11 Jan 2012 Discontinued - Phase-I for Malignant melanoma in New Zealand (IV)
  • 11 Jan 2012 Discontinued - Phase-I for Malignant melanoma in United Kingdom (IV)
  • 11 Jan 2012 Discontinued - Phase-I for Renal cancer in New Zealand (IV)
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