Denosumab - Amgen

Drug Profile

Denosumab - Amgen

Alternative Names: AMG-162; PRALIA; Prolia; Ranmark; Xgeva

Latest Information Update: 28 Sep 2018

Price : $50 *
* Final gross price and currency may vary according to local VAT and billing address.
* Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase. A link to download a PDF version of the drug profile will be included in your email receipt. Adis is an information provider. We do not sell or distribute the pharmaceutical compounds written about in this database.

At a glance

  • Originator Amgen
  • Developer Amgen; Daiichi Sankyo Company; European Thoracic Oncology Platform; GlaxoSmithKline; Jules Bordet Institute; Melbourne Health; University Health Network
  • Class Antihypercalcaemics; Antineoplastics; Antirheumatics; Calcium regulators; Monoclonal antibodies; Osteoporosis therapies
  • Mechanism of Action RANK ligand inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant hypercalcaemia; Bone cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Bone cancer; Bone disorders; Bone metastases; Corticosteroid-induced osteoporosis; Male osteoporosis; Malignant hypercalcaemia; Osteoporosis; Postmenopausal osteoporosis; Rheumatoid arthritis
  • Phase III Breast cancer; Non-small cell lung cancer; Osteogenesis imperfecta
  • Phase II Malignant melanoma
  • No development reported Multiple myeloma

Most Recent Events

  • 04 Sep 2018 Phase-II clinical trials in Bone metastases (Combination therapy, Metastatic disease) in Canada (SC) (NCT03520231)
  • 01 Sep 2018 Phase-II clinical trials in Malignant melanoma (Inoperable/Unresectable, Combination therapy, Metastatic disease) in USA (SC) (NCT03620019)
  • 10 Aug 2018 Amgen completes a phase III access study for Bone metastases who have completed previous phase III trial in Argentina, Austria, Belgium, Brazil, Czech Republic, France, Hungary, India, Israel, Italy, Japan, Latvia, Lithuania, Panama, Peru, Poland, Russia, South Africa, Spain, and Ukraine (NCT01419717)
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at so we can help.

Back to top