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Intepirdine - GSK/Sio Gene Therapies

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Drug Profile

Intepirdine - GSK/Sio Gene Therapies

Alternative Names: 742457; GSK 742457; RVT-101; SB-742457

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator GlaxoSmithKline
  • Developer Axovant Sciences; GlaxoSmithKline
  • Class Antidementias; Nootropics; Small molecules
  • Mechanism of Action Serotonin 6 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alzheimer's disease; Dementia; Lewy body disease

Most Recent Events

  • 10 Nov 2020 Axovant Gene Therapies is now called Sio Gene Therapies
  • 01 Mar 2018 Axovant Sciences terminates the phase III MINDSET EXTENSION trial for Alzheimer's disease (Treatment-experienced) in USA, Argentina, Australia, Bulgaria, Canada, Chile, Croatia, Czech Republic, France, Germany, Italy, South Korea, Poland, Serbia, Singapore, Slovakia, Spain, Taiwan, and the United Kingdom (PO) (NCT02586909)
  • 13 Feb 2018 Axovant Sciences terminates the phase II/III HEADWAY-DLB Extension trial as intepirdine did not meet its primary efficacy endpoints in the lead-in study RVT-101-2001 for Lewy body disease in USA, United Kingdom, Spain, Netherlands, Canada, France and Italy (PO, Tablet) (NCT02928445)

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