Orvepitant - NeRRe therapeutics

Drug Profile

Orvepitant - NeRRe therapeutics

Alternative Names: 823296; GW 823296; GW823296X

Latest Information Update: 31 May 2018

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At a glance

  • Originator GlaxoSmithKline
  • Developer NeRRe Therapeutics
  • Class Amides; Antidepressants; Antipruritics; Antitussives; Anxiolytics; Piperidines; Pyrazines; Pyrroles
  • Mechanism of Action Neurokinin 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Cough; Pruritus
  • Discontinued Anxiety disorders; Major depressive disorder; Post-traumatic stress disorders

Most Recent Events

  • 24 May 2018 Nerre Therapeutics plans a phase I study to assess the effect of itraconazole on the pharmacokinetics of orvepitant in healthy volunteers (NCT03535662)
  • 09 May 2018 Nerre Therapeutics withdraws the phase II SOOTHE trial for Pruritus associated with atopic dermatitis prior to enrolment due to strategic decision (PO) (NCT03464526)
  • 14 Mar 2018 Nerre Therapeutics plans the SOOTHE phase II trial for Pruritus associated with atopic dermatitis in May 2018 (PO) , (NCT03464526)
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