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Drug Profile


Alternative Names: ALT 110; Brain cancer vaccine - Celldex Therapeutics; CDX-110; PF-04948568; PF-04948569; PF-4948568; PF-4948569; Rindo; Rintega; SPX 110

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Duke University; Johns Hopkins University
  • Developer Celldex Therapeutics Inc
  • Class Cancer vaccines; Peptide vaccines; Peptides
  • Mechanism of Action Epidermal growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Glioblastoma; Solid tumours

Most Recent Events

  • 16 Oct 2017 Expanded access no longer available for rindopepimut in Glioblastoma (Recurrent, Second-line therapy or greater) (NCT03068650)
  • 08 Aug 2016 Discontinued - Phase-I for Solid tumours in USA (Intradermal)
  • 08 Aug 2016 Discontinued - Phase-II for Glioblastoma (Combination therapy, Second-line therapy or greater) in USA (Intradermal)
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