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Dapirolizumab pegol - Biogen/UCB

Drug Profile

Dapirolizumab pegol - Biogen/UCB

Alternative Names: Anti-CD40L Fab; Anti-CD40L Fab-PEG; CD40L - Fab; CDP-7657; Peg-dapirolizumab; Pegylated anti-CD40L antibody

Latest Information Update: 22 Jun 2019

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At a glance

  • Originator Biogen Idec; UCB
  • Developer Biogen; UCB
  • Class Antibodies; Antirheumatics; Fab fragments; Monoclonal antibodies; Polyethylene glycols
  • Mechanism of Action CD40 ligand inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Systemic lupus erythematosus
  • No development reported Amyotrophic lateral sclerosis; Rheumatoid arthritis

Most Recent Events

  • 24 Jul 2019 UCB in collaboration with Biogen plans to initiate a phase III trial for Systemic lupus erythematosus (SLE) in the first half of 2020.
  • 12 Jun 2019 Interim efficacy, adverse events and pharmacodynamics data from a phase IIb trial in systemic lupus erythematosus were presented at the 20th Annual Congress of the European League Against Rheumatism (EULAR-2019)
  • 15 Nov 2018 UCB completes a phase II trial in Systemic lupus erythematosus (Adjunctive treatment) in USA, Bulgaria, Germany, Hungary, Spain, Ukraine, Russia, Romania, Poland, Peru, Mexico, Colombia, Chile (IV) (NCT02804763)
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