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Research programme: siRNA therapeutics - Silence Therapeutics

Drug Profile

Research programme: siRNA therapeutics - Silence Therapeutics

Alternative Names: Atu014; Atu093; Atu111; Atu134; Atu150; Atu195; AtuRNAi; Soluble Fms-like Tyrosine Kinase-1-specific SiRNA

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Atugen AG
  • Developer Charite of Berlin; McGill University; Sanofi; Silence Therapeutics; Silence Therapeutics plc
  • Class Antihyperglycaemics; Antihypertensives; Antineoplastics; Small interfering RNA
  • Mechanism of Action Endothelin A receptor antagonists; Protein kinase N3 inhibitors; RNA interference; Vascular endothelial growth factor receptor-1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Acute lung injury; Solid tumours

Highest Development Phases

  • Preclinical Preeclampsia; Pulmonary arterial hypertension
  • No development reported Acute lung injury
  • Discontinued Diabetes mellitus; Solid tumours; Wounds

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for preclinical development in Acute-lung-injury in Germany (Parenteral)
  • 14 Sep 2017 Preclinical trials in Preeclampsia in England (IV)
  • 14 Sep 2017 Pharmacodynamics data from a preclinical study in Preclampsia presented at the Council on Hypertension Scientific Session 2017 (AHA-ASH-2017)
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