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Idetrexed - Algok Bio

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Drug Profile

Idetrexed - Algok Bio

Alternative Names: BGC-945; BTG-945; CT-900; ONX-0801; ONX-0901

Latest Information Update: 19 Aug 2025

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At a glance

  • Originator The Institute of Cancer Research
  • Developer Algok Bio; Onyx Pharmaceuticals; Royal Marsden NHS Foundation Trust; The Institute of Cancer Research
  • Class Antineoplastics; Cyclopentanes; Glutamates; Quinazolines; Small molecules
  • Mechanism of Action Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Ovarian cancer
  • No development reported Solid tumours

Most Recent Events

  • 13 Aug 2025 Phase-I clinical trials in Ovarian cancer (Combination therapy, Second-line therapy or greater) in United Kingdom (IV) (NCT06976892)
  • 28 May 2025 No recent reports of development identified for phase-I development in Solid-tumours(In the elderly, Second-line therapy or greater, Treatment-resistant, In adults) in United Kingdom (IV, Infusion)
  • 16 May 2025 Institute of Cancer Research in collaboration with Algok Bio plans a phase I/Ib trial for Ovarian Cancer (Combination therapy, Late stage disease, First line therapy) in United Kingdom (IV), in May 2025 (NCT06976892)

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