Canakinumab- Novartis

Drug Profile

Canakinumab- Novartis

Alternative Names: ACZ-885; Anti-IL-1 beta monoclonal antibody; Anti-interleukin-1 beta monoclonal antibody; Antibody A; Ilaris

Latest Information Update: 24 Apr 2018

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At a glance

  • Originator Novartis
  • Developer Charite - Universitatsmedizin Berlin; Novartis; Triemli hospital; University Hospital Tubingen; University Hospital Zurich
  • Class Anti-inflammatories; Antihyperglycaemics; Antirheumatics; Cardiovascular therapies; Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Interleukin 1 beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Juvenile rheumatoid arthritis; Inflammation; Familial Mediterranean fever; Familial autosomal dominant periodic fever
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Adult-onset Still's disease; Cryopyrin-associated periodic syndromes; Familial autosomal dominant periodic fever; Familial Mediterranean fever; Gouty arthritis; Juvenile rheumatoid arthritis; Peroxisomal disorders
  • Preregistration Cardiovascular disorders
  • Phase III Behcet's syndrome; Non-small cell lung cancer
  • Phase II Abdominal aortic aneurysm; Atherosclerosis; Osteoarthritis; Peripheral arterial occlusive disorders; Pulmonary sarcoidosis; Schnitzler syndrome; Sickle cell anaemia
  • No development reported Chronic obstructive pulmonary disease
  • Discontinued Asthma; Diabetic retinopathy; Polymyalgia rheumatica; Rheumatoid arthritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Most Recent Events

  • 22 Feb 2018 Phase-III clinical trials in Non-small cell lung cancer (Adjuvant therapy) in Greece (SC) (Novartis pipeline, February 2018) (NCT03447769)
  • 22 Feb 2018 Discontinued - Phase-I for Diabetic retinopathy in Switzerland (SC)
  • 22 Feb 2018 Phase-III clinical trials in Non-small cell lung cancer (Adjuvant therapy) in Germany (SC) (Novartis pipeline, February 2018) (NCT03447769)
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