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Canakinumab - Novartis

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Drug Profile

Canakinumab - Novartis

Alternative Names: ACZ-885; Anti-IL-1 beta monoclonal antibody; Antibody A; Ilaris

Latest Information Update: 28 May 2024

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At a glance

  • Originator Novartis
  • Developer Charite - Universitatsmedizin Berlin; Columbia University; Novartis; Triemli hospital; University Hospital Tubingen; University Hospital Zurich
  • Class Anti-inflammatories; Antianaemics; Antigouts; Antihyperglycaemics; Antineoplastics; Antirheumatics; Cardiovascular therapies; Eye disorder therapies; Heart failure therapies; Immunotherapies; Monoclonal antibodies; Vascular disorder therapies
  • Mechanism of Action Interleukin 1 beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Familial Mediterranean fever; Pancreatic cancer; Juvenile rheumatoid arthritis; Inflammation; Cryopyrin-associated periodic syndromes; Peroxisomal disorders; Familial autosomal dominant periodic fever; Adult-onset Still's disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Adult-onset Still's disease; Cryopyrin-associated periodic syndromes; Familial autosomal dominant periodic fever; Familial Mediterranean fever; Gouty arthritis; Juvenile rheumatoid arthritis; Peroxisomal disorders
  • Preregistration Cardiovascular disorders
  • Phase III Behcet's syndrome; COVID 2019 infections; COVID-19 pneumonia; Cytokine release syndrome; Non-small cell lung cancer
  • Phase II Abdominal aortic aneurysm; Alcoholic hepatitis; Alzheimer's disease; Atherosclerosis; Heart failure; Malignant melanoma; Mild cognitive impairment; Myelodysplastic syndromes; Osteoarthritis; Peripheral arterial occlusive disorders; Pulmonary sarcoidosis; Respiratory insufficiency; Schnitzler syndrome; Sickle cell anaemia
  • No development reported Chronic obstructive pulmonary disease; Pancreatic cancer; Renal cell carcinoma; Triple negative breast cancer
  • Discontinued Asthma; Diabetic retinopathy; Polymyalgia rheumatica; Rheumatoid arthritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Most Recent Events

  • 28 May 2024 No recent reports of development identified for phase-I development in Myelodysplastic-syndromes(Combination therapy, Second-line therapy or greater) in Singapore (SC)
  • 28 May 2024 No recent reports of development identified for phase-I development in Myelodysplastic-syndromes(Monotherapy, Second-line therapy or greater) in Singapore (SC)
  • 17 May 2024 Novartis terminates a phase-I trial in Myelodysplastic syndromes (Monotherapy, Combination therapy, Second-line therapy or greater) in Spain, South Korea, Italy, Israel, Australia, USA (SC) due to business reasons (NCT04810611)
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