Research programme: microRNA therapeutics - Regulus Therapeutics

Drug Profile

Research programme: microRNA therapeutics - Regulus Therapeutics

Alternative Names: anti-miR-10b; anti-miR-122; miR-296; miR-34; miR-34a; miR-K12-11 (viral oncomir); miR-X; miRNA therapeutics - Regulus Therapeutics; Viral microRNAs - Regulus Therapeutics

Latest Information Update: 03 Oct 2018

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At a glance

  • Originator California Institute of Technology/CalTech; Stanford University
  • Developer Cenix BioScience; Regulus Therapeutics
  • Class Antisense oligonucleotides; MicroRNAs
  • Mechanism of Action MicroRNA inhibitors; MicroRNA modulators; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Glioblastoma; Hepatitis B; Hepatitis C; Non-alcoholic steatohepatitis
  • Discontinued Diabetes mellitus; Heart failure; Metabolic syndrome; Viral infections

Most Recent Events

  • 26 Sep 2018 Pharmacodynamics data from preclinical studies in Non-alcoholic steatohepatitis, Glioblastoma and Hepatitis B released by Regulus Therapeutics
  • 20 Aug 2018 Preclinical trials in Hepatitis B in USA (unspecified route), prior August 2018
  • 06 Jul 2018 Regulus Therapeutics expects to file an IND for the HBV program in second half of 2019
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