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Marizomib - Celgene Corporation

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Drug Profile

Marizomib - Celgene Corporation

Alternative Names: CC-92763; MRZ; NPI-0052; Salinosporamide A

Latest Information Update: 01 Aug 2024

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At a glance

  • Originator Nereus Pharmaceuticals
  • Developer Canadian Cancer Trials Group; Celgene Corporation; European Organisation for Research and Treatment of Cancer; National Cancer Institute (USA); Triphase Accelerator Corporation
  • Class Anti-inflammatories; Antineoplastics; Lactones; Pyrroles; Small molecules
  • Mechanism of Action Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Glioblastoma
  • Phase II Ependymoma; Multiple myeloma
  • No development reported Diffuse intrinsic pontine glioma; Lymphoma; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 03 Mar 2024 Dana-Farber Cancer Institute withdrawn phase-II trial in Multiple myeloma (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA (IV, infusion) before enrolment due to study support withdrawn (NCT05050305)
  • 26 Feb 2024 Dana-Farber Cancer Institute terminates phase I trial in Diffuse intrinsic pontine glioma (In children, In adults, In adolescents, Monotherapy, Second-line therapy or greater) in USA (PO) due to withdrawal of support from BMS (NCT04341311)
  • 14 Feb 2024 Dana-Farber Cancer Institute terminates phase I trial in Glioma (In children, In adults, In adolescents, Combination therapy, Second-line therapy or greater) in USA (PO) due to withdrawal of support from BMS (NCT04341311)

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