Drug Profile


Alternative Names: MRZ; NPI-0052; Salinosporamide A

Latest Information Update: 19 Sep 2018

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At a glance

  • Originator Nereus Pharmaceuticals
  • Developer Celgene Corporation; European Organisation for Research and Treatment of Cancer; Triphase Accelerator Corporation
  • Class Anti-inflammatories; Antineoplastics; Lactones; Pyrroles; Small molecules
  • Mechanism of Action Apoptosis stimulants; Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Glioblastoma
  • Phase II Multiple myeloma
  • No development reported Cancer; Lymphoma; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 26 Jul 2018 Phase-III clinical trials in Glioblastoma (Combination therapy, First-line therapy, Newly diagnosed, Adjuvant therapy) in Spain, Norway (IV) (NCT03345095)
  • 26 Jul 2018 Phase-III clinical trials in Glioblastoma (Newly diagnosed, Combination therapy, Adjuvant therapy, First-line therapy) in Netherlands (IV) (NCT03345095)
  • 28 Jun 2018 No recent reports of development identified for preclinical development in Cancer in USA (PO)
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