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Tremelimumab - AstraZeneca

Drug Profile

Tremelimumab - AstraZeneca

Alternative Names: Anti CTLA 4 monoclonal antibody-Pfizer; Anti-CTLA4 Human Monoclonal Antibody CP-675,206; CP-675; CP-675206; Human IgG2 mAb tremelimumab - AstraZeneca; Ticilimumab

Latest Information Update: 19 Oct 2021

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At a glance

  • Originator Pfizer
  • Developer AIO Studien gGmbH; Amgen; ARCAGY/GINECO Group; AstraZeneca; Azienda Ospedaliera Universitaria Senese; Canadian Cancer Trials Group; Charite - Universitatsmedizin Berlin; Dana-Farber Cancer Institute; Fondazione IRCCS Istituto Nazionale dei Tumori; GlaxoSmithKline; Grupo Espanol de Tumores Neuroendocrinos; Hoosier Cancer Research Network; Immunocore; Institute for Clinical Cancer Research IKF GmbH at Krankenhaus Nordwest; Institute Gustave-Roussy; Kyoto Breast Cancer Research Network; M. D. Anderson Cancer Center; MedImmune; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Northwestern University; Pfizer; Seoul National University Hospital; UNICANCER; University College London; University of Maryland Greenbaum Cancer Center; VU University Medical Center; Yonsei University College of Medicine
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Bladder cancer; Head and neck cancer; Liver cancer; Mesothelioma; Non-small cell lung cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Urogenital cancer
  • Phase II Biliary cancer; Breast cancer; Cervical cancer; Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Fallopian tube cancer; Gallbladder cancer; Gastric cancer; Gastrointestinal cancer; Germ cell and embryonal neoplasms; Glioblastoma; Lung cancer; Neuroendocrine tumours; Oesophageal cancer; Oropharyngeal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Sarcoma; Soft tissue sarcoma; Thyroid cancer
  • Phase I/II Haematological malignancies; Malignant melanoma
  • No development reported Diffuse large B cell lymphoma; Gynaecological cancer; Myelodysplastic syndromes; Vulvovaginal cancer

Most Recent Events

  • 15 Oct 2021 Efficacy and adverse events data from the phase III HIMALAYA trial in Liver cancer released by AstraZeneca
  • 09 Sep 2021 Updated efficacy and adverse events data from phase III POSEIDON trial in Non-small cell lung cancer released by AstraZeneca
  • 30 Aug 2021 University of Cincinnati plans a phase II trial for Liver cancer (Combination therapy, First-line therapy) (IV) in October 2021 (NCT05027425)
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