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Tremelimumab - AstraZeneca

Drug Profile

Tremelimumab - AstraZeneca

Alternative Names: Anti CTLA 4 monoclonal antibody - AstraZeneca; CP-675; CP-675,206; IMJUDO; Ticilimumab

Latest Information Update: 17 May 2024

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At a glance

  • Originator Pfizer
  • Developer Amgen; AstraZeneca; Cancer Research Institute; Dana-Farber Cancer Institute; Immunocore; MedImmune; Pfizer; University of Alabama at Birmingham
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Liver cancer; Non-small cell lung cancer
  • Phase III Bladder cancer; Head and neck cancer; Malignant-mesothelioma; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Urogenital cancer
  • Phase II Biliary cancer; Breast cancer; Cervical cancer; Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Fallopian tube cancer; Gallbladder cancer; Gastric cancer; Gastrointestinal cancer; Germ cell cancer; Glioblastoma; HER2 negative breast cancer; Lung cancer; Neuroendocrine tumours; Oesophageal cancer; Oropharyngeal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Sarcoma; Soft tissue sarcoma; Squamous cell cancer; Thyroid cancer
  • Phase I/II Haematological malignancies; Malignant melanoma
  • No development reported Diffuse large B cell lymphoma; Gynaecological cancer; Myelodysplastic syndromes; Vulvovaginal cancer

Most Recent Events

  • 01 May 2024 University of Alabama at Birmingham terminates a I/II trial for Cholangiocarcinoma (Combination therapy) in USA (IV) due to slow accrual and study sponsor decision (NCT04989218)
  • 31 Jan 2024 AstraZeneca initiates the phase IIIb TRITON trial in Non-small cell lung cancer (Late-stage disease, Metastatic disease, First-line therapy, Combination therapy) in USA (IV) (NCT06008093)
  • 18 Jan 2024 Efficacy and adverse events data from a phase Ib DEPARTURE trial in Liver cancer presented at the 2024 Gastrointestinal Cancers Symposium (ASCO-GCS-2024 2024)
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