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Tremelimumab - AstraZeneca

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Drug Profile

Tremelimumab - AstraZeneca

Alternative Names: Anti CTLA 4 monoclonal antibody - AstraZeneca; CP-675; CP-675,206; IMJUDO; Ticilimumab

Latest Information Update: 21 Nov 2024

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At a glance

  • Originator Pfizer
  • Developer AstraZeneca; Cancer Research Institute; Dana-Farber Cancer Institute; MedImmune; Pfizer; University of Alabama at Birmingham
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer; Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Liver cancer; Non-small cell lung cancer
  • Phase III Bladder cancer; Head and neck cancer; Malignant-mesothelioma; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Urogenital cancer
  • Phase II Biliary cancer; Breast cancer; Cervical cancer; Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Fallopian tube cancer; Gallbladder cancer; Gastric cancer; Gastrointestinal cancer; Germ cell cancer; Glioblastoma; HER2 negative breast cancer; Lung cancer; Neuroendocrine tumours; Oesophageal cancer; Oropharyngeal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Sarcoma; Soft tissue sarcoma; Squamous cell cancer; Thyroid cancer
  • Phase I/II Haematological malignancies
  • No development reported Vulvovaginal cancer
  • Discontinued Diffuse large B cell lymphoma; Gynaecological cancer; Malignant melanoma; Myelodysplastic syndromes

Most Recent Events

  • 12 Nov 2024 rupo Espanol de Tumores Neuroendocrinos terminates phase II trial in Thyroid cancer (Combination therapy, Late-stage disease) in Spain (NCT03753919) (EudraCT-2018-001066-42)
  • 28 Sep 2024 No recent reports of development identified for phase-I development in HER2-negative-breast-cancer(Combination therapy, Neoadjuvant therapy) in USA (IV, Infusion)
  • 28 Sep 2024 No recent reports of development identified for phase-I development in Vulvovaginal-cancer(Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (IV, Infusion)

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