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GI 4000

Drug Profile

GI 4000

Alternative Names: GI-4000

Latest Information Update: 13 Sep 2019

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At a glance

  • Originator GlobeImmune
  • Developer GlobeImmune; NantCell; NantKwest
  • Class Cancer vaccines
  • Mechanism of Action Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Breast cancer; Colorectal cancer; Pancreatic cancer
  • Suspended Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 29 Aug 2019 NantKwest withdraws the phase Ib/II QUILT-3.049 trial for Triple negative breast cancer (Second-line therapy or greater, Metastatic disease, Inoperable/Unresectable, Combination therapy) prior to initiation (NCT03175666)
  • 27 Aug 2019 NantKwest withdraws the QUILT-2.024 phase II trial prior to enrolment for Non Small Cell Lung Cancer (Late-stage disease) as the trial was not initiated (NCT03574649)
  • 23 Aug 2019 NantCell withdraws the phase Ib/II QUILT-3.044 trial prior to enrolment for Non-small cell lung cancer (Combination therapy, Second-line therapy or greater) as the trial was not initiated (NCT03169738)
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