Palbociclib - Pfizer

Drug Profile

Palbociclib - Pfizer

Alternative Names: Ibrance; Iburance; Parvociclib; PD-0332991; PD-332991; PD-991; PF-332991

Latest Information Update: 11 Oct 2018

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At a glance

  • Originator Onyx Pharmaceuticals; Pfizer
  • Developer Assistance Publique Hopitaux de Paris; Bergonie Institute; Canadian Cancer Trials Group; Dana-Farber Cancer Institute; Georgetown University; German Breast Group; GlaxoSmithKline; Grupo Espanol de Tumores Neuroendocrinos; iOMEDICO AG; Karolinska Institute; National Cancer Institute (USA); Netherlands Cancer Institute; Northwestern University; Pfizer; UNC Lineberger Comprehensive Cancer Center; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
  • Class 2 ring heterocyclic compounds; Antineoplastics; Cyclopentanes; Ketones; Piperazines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase II/III Non-small cell lung cancer
  • Phase II Brain metastases; Colorectal cancer; Gastrointestinal stromal tumours; Head and neck cancer; Pancreatic cancer; Prostate cancer; Urogenital cancer
  • Phase I/II Cancer; Malignant melanoma
  • Phase I Acute myeloid leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
  • No development reported Glioblastoma; Mantle-cell lymphoma; Multiple myeloma

Most Recent Events

  • 05 Oct 2018 Pfizer collaborates with Calithera Biosciences to conduct clinical trials with CB 839, palbociclib and talazoparib
  • 01 Oct 2018 Emory University and Pfizer plan the phase II ASPIRE trial for Breast cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (NCT03691493)
  • 25 Jun 2018 Efficacy and adverse events data from the phase III PALOMA trial in Breast cancer released by Pfizer
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