Drug Profile
Palbociclib - Onyx Pharmaceuticals/Pfizer
Alternative Names: IBRANCE; Ibrance; Iburance; Parvociclib; PD-0332991; PD-332991; PD-991; PF-332991Latest Information Update: 15 Mar 2024
Price :
$50
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At a glance
- Originator Onyx Pharmaceuticals; Pfizer; SOLTI Breast Cancer Research Group
- Developer Assistance Publique Hopitaux de Paris; Bergonie Institute; Calithera Biosciences; Canadian Cancer Trials Group; Celgene Corporation; Dana-Farber Cancer Institute; Emory University; European Organisation for Research and Treatment of Cancer; Georgetown University; German Breast Group; Grupo Espanol de Tumores Neuroendocrinos; GSK; International Breast Cancer Study Group; iOMEDICO AG; Karolinska Institute; National Cancer Institute (USA); Northwestern University; Pfizer; UNC Lineberger Comprehensive Cancer Center; UNICANCER; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
- Class 2 ring heterocyclic compounds; Antineoplastics; Cyclopentanes; Ketones; Piperazines; Pyridines; Pyrimidines; Small molecules
- Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Breast cancer
- Phase III HER2 negative breast cancer
- Phase II/III Non-small cell lung cancer
- Phase II Bone metastases; Brain metastases; Gastrointestinal stromal tumours; Mantle-cell lymphoma; Pancreatic cancer; Prostate cancer; Squamous cell cancer; Urogenital cancer
- Phase I/II Colorectal cancer; Malignant melanoma
- No development reported Acute myeloid leukaemia; Glioblastoma; Multiple myeloma; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
- Discontinued Astrocytoma; Glioma
Most Recent Events
- 01 Mar 2024 University of Kansas Medical Center and Pfizer terminate a phase I/II trial in HER2-positive Breast Cancer in USA (PO) due to low accrual (NCT03709082)
- 06 Dec 2023 Georgetown University terminates phase II trial in Breast cancer (Monotherapy, Neoadjuvant therapy) in USA (PO), due to lack of accrual (NCT03535506)
- 05 Dec 2023 Efficacy and adverse events data from a phase II trial in Bone metastases presented at the 46th Annual San Antonio Breast Cancer Symposium (SABCS-2023)