Drug Profile

Mirdametinib - SpringWorks Therapeutics

Alternative Names: EZMEKLY; GOMEKLI; PD-0325901; PD-325901

Latest Information Update: 17 Dec 2025

Price :

$50 ^*

Note:

Adis is an information provider. We do not sell or distribute actual drugs.
Final gross price and currency may vary according to local VAT and billing address.
Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase.
A link to download a PDF version of the drug profile will be included in your email receipt.

At a glance

Originator Pfizer
Developer BeOne Medicines; Pfizer; SpringWorks Therapeutics; St. Jude Childrens Research Hospital
Class Aniline compounds; Antineoplastics; Benzamides; Fluorinated hydrocarbons; Iodinated hydrocarbons; Small molecules
Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Neurofibromatosis 1
New Molecular Entity Yes
Available For Licensing Yes

Registered Neurofibromatosis 1
Phase II Histiocytosis; Malignant melanoma; Vascular malformations
Phase I/II Glioma; Solid tumours
Phase 0 Nerve sheath neoplasms
Preclinical Aortic aneurysm
Discontinued Breast cancer; Cancer; Cervical cancer; Chronic obstructive pulmonary disease; Colorectal cancer; Non-small cell lung cancer

12 Dec 2025 SpringWorks Therapeutics plans phase I pharmacokinetics trial (In volunteers) in US in December 2025 (PO) (NCT07279233)
26 Nov 2025 Springworks Therapeutics plans a phase I trial for Neurofibromatosis 1 (In infants, In neonates, In children, In adolescents) in Germany and Spain (PO) (CTIS2025-522000-24-00)
13 Oct 2025 Phase-II clinical trials in Malignant melanoma (Late-stage disease, Metastatic disease, Second-line therapy or greater, Inoperable/Unresectable) in USA (PO) (NCT07237100)

If your organization or you do not have a subscription, try one of the following:

Contacting your organization’s admin about adding this content to your AdisInsight subscription
Buying a PDF version of any individual profile
Request a free trial (opens in a new window)

If your organization has a subscription, there are several access options, even while working remotely:

Working within your organization’s network
Login with username/password or try to access via your institution
Persisted access using your organization’s identifier stored in your user browser for 90 days

For assistance, contact us at asktheexpert.adisinsight@springer.com