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Drug Profile


Alternative Names: 99mTc-MAG3-BIIB067; BIIB 067; ISIS 333611; ISIS-SOD1Rx; SODr/h333611

Latest Information Update: 29 Jan 2019

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At a glance

  • Originator Center for Neurologic Study; Isis Pharmaceuticals; Ludwig Institute for Cancer Research
  • Developer Biogen; Ionis Pharmaceuticals
  • Class Antisense oligonucleotides
  • Mechanism of Action Superoxide dismutase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Amyotrophic lateral sclerosis

Most Recent Events

  • 20 Dec 2018 Phase-I clinical trials in Amyotrophic lateral sclerosis (In volunteers) in USA (Intrathecal) (NCT03764488)
  • 06 Dec 2018 Interim efficacy data from a (phase I/II trial in Amyotrophic lateral sclerosis released by Biogen and Ionis (9256321)
  • 06 Dec 2018 Biogen plans a pivotal trial for Amyotrophic lateral sclerosis
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