Linaclotide - Ironwood Pharmaceuticals

Drug Profile

Linaclotide - Ironwood Pharmaceuticals

Alternative Names: ASP-0456; ASP-456; Constella; Linaclotide acetate; Linzess; MD-1100; MM-416775

Latest Information Update: 13 Jul 2018

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At a glance

  • Originator Microbia
  • Developer Allergan; Astellas Pharma; AstraZeneca; Ironwood Pharmaceuticals
  • Class Gastrokinetics; Irritable bowel syndrome therapies; Oligopeptides
  • Mechanism of Action Guanylate cyclase C agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Constipation; Irritable bowel syndrome

Highest Development Phases

  • Marketed Constipation; Irritable bowel syndrome
  • Preclinical Visceral pain

Most Recent Events

  • 04 Jul 2018 Ironwood Pharmaceuticals and Allergan initiate a phase III trial for Linaclotide for Irritable bowel syndrome in USA (NCT03573908)
  • 29 May 2018 Ironwood Pharmaceuticals completes a phase II trial in Constipation (In children, In adolescents) in USA and Canada (PO; Capsule, Solution) (NCT02559570)
  • 03 May 2018 Ironwood Pharmaceuticals and Allergan enters into settlement agreement with Aurobindo Pharma to resolve linaclotide patent litigation
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