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Plinabulin - BeyondSpring Pharmaceuticals

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Drug Profile

Plinabulin - BeyondSpring Pharmaceuticals

Alternative Names: BPI 2358; NPI 2358

Latest Information Update: 26 Aug 2025

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At a glance

  • Originator Nereus Pharmaceuticals
  • Developer BeyondSpring Pharmaceuticals; Big Ten Cancer Research Consortium; M. D. Anderson Cancer Center; Nereus Pharmaceuticals; Rutgers Cancer Institute of New Jersey
  • Class Antineoplastics; Imidazoles; Piperazines; Small molecules
  • Mechanism of Action Antigen presenting cell stimulants; Guanine nucleotide exchange factor stimulants; Tubulin modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Neutropenia
  • Phase III Non-small cell lung cancer
  • Phase II Small cell lung cancer
  • Phase I/II Cancer
  • Preclinical Bladder cancer; Gastric cancer; Soft tissue sarcoma
  • No development reported Brain cancer; Breast cancer; Glioblastoma; Sickle cell anaemia; Solid tumours

Most Recent Events

  • 13 Aug 2025 Efficacy data from a phase-Ib/II trial in Cancer released by BeyondSpring Pharmaceuticals
  • 13 Aug 2025 Updated efficacy data from a phase-II trial in Non-small cell lung cancer released by BeyondSpring Pharmaceuticals
  • 04 Jun 2025 Efficacy and adverse events data from phase-II KeyPemls-004 trial in Non-small cell lung cancer released by BeyondSpring Pharmaceuticals

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