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Plinabulin - BeyondSpring Pharmaceuticals

Drug Profile

Plinabulin - BeyondSpring Pharmaceuticals

Alternative Names: BPI 2358; NPI 2358

Latest Information Update: 10 Jan 2019

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At a glance

  • Originator Nereus Pharmaceuticals
  • Developer BeyondSpring Pharmaceuticals; Big Ten Cancer Research Consortium; National Cancer Institute (USA); Nereus Pharmaceuticals; Rutgers Cancer Institute of New Jersey; University of Washington
  • Class Antineoplastics; Imidazoles; Piperazines; Small molecules
  • Mechanism of Action Guanine nucleotide exchange factor stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Neutropenia; Non-small cell lung cancer
  • Phase I/II Small cell lung cancer
  • Preclinical Glioblastoma
  • Research Brain cancer
  • No development reported Solid tumours

Most Recent Events

  • 21 Dec 2018 USPTO issues a new composition of matter patent to plinabulin in USA
  • 01 Dec 2018 Updated efficacy data from the phase II/III Protective 1 trial in Neutropenia (Chemotherapy-induced, Combination therapy, Prevention) presented at the 60th Annual Meeting and Exposition of the American Society of Haematology (ASH-Hem-2018)
  • 27 Nov 2018 BeyondSpring Pharmaceuticals has patent protection for plinabulin in Chemotherapy induced neutropenia (CIN) in Japan
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