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Mocetinostat - Mirati Therapeutics

Drug Profile

Mocetinostat - Mirati Therapeutics

Alternative Names: MG-0103; MGCD-0103; MGCD103; Mocetinostat dihydrobromide

Latest Information Update: 18 Nov 2018

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At a glance

  • Originator MethylGene
  • Developer MedImmune; MethylGene; Mirati Therapeutics; New York University School of Medicine
  • Class Antineoplastics; Benzamides; Pyrimidines; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes; Diffuse large B cell lymphoma; Hodgkin's disease
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bladder cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Myelodysplastic syndromes; Non-small cell lung cancer
  • Phase I/II Solid tumours
  • Phase I Malignant melanoma
  • No development reported Chronic lymphocytic leukaemia
  • Discontinued Acute myeloid leukaemia; Hodgkin's disease

Most Recent Events

  • 02 Oct 2018 Updated adverse events and efficacy data from a phase II trial in Non-small cell lung cancer released by Mirati Therapeutics
  • 24 Jun 2018 Biomarkers information updated
  • 25 Apr 2018 Phase-I clinical trials in Malignant melanoma (Combination therapy, Late-stage disease) in USA (PO) (NCT03565406)
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