BNC 105

Drug Profile

BNC 105

Alternative Names: BNC 105P; BNC-105

Latest Information Update: 30 May 2017

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At a glance

  • Originator Iliad Chemicals
  • Developer Bionomics
  • Class Anisoles; Antineoplastics; Benzofurans; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Apoptosis stimulants; Tubulin polymerisation inhibitors; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Mesothelioma; Renal cell carcinoma
  • Phase I/II Ovarian cancer
  • Preclinical Chronic lymphocytic leukaemia; Colorectal cancer

Most Recent Events

  • 05 Mar 2018 Dartmouth-Hitchcock Medical Center plans a phase I trial of BNC 105P (Combination therapy, Second-line therapy or greater) in Chronic lymphocytic leukaemia in March 2018 (NCT03454165)
  • 01 Dec 2016 Bionomics completes a phase I/II trial in Renal cell carcinoma (Combination therapy, Metastatic disease, Second-line therapy or greater) in Singapore, Australia (IV) (NCT01034631)
  • 28 Aug 2015 BNC 105 is still in phase II development for mesothelioma, renal cell carcinoma and phase I/II development for ovarian cancer in Australia, New Zealand and USA
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