Trans-sodium crocetinate - Diffusion Pharmaceuticals

Drug Profile

Trans-sodium crocetinate - Diffusion Pharmaceuticals

Alternative Names: Crocetin sodium salt; Sodium crocetinate; Trans sodium crocetinate; Transcrocetinate sodium; TSC; TSC-cpd

Latest Information Update: 18 Sep 2018

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At a glance

  • Originator University of Virginia
  • Developer Diffusion Pharmaceuticals
  • Class Antineoplastics; Carotenoids; Radiation-sensitising agents; Small molecules; Vascular disorder therapies
  • Mechanism of Action Oxygen compound modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Brain metastases
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Glioblastoma
  • Preclinical Brain metastases; Pancreatic cancer; Stroke
  • Discontinued Peripheral arterial disorders

Most Recent Events

  • 12 Sep 2018 US FDA approves an IND application to enrol patient in the phase II PHAST-TSC trial for trans-sodium crocetinate in acute Stroke
  • 13 Aug 2018 Diffusion Pharmaceuticals, in collaboration with the University of California Los Angeles and the University of Virginia, plans a phase II PHAST-T (Pre-Hospital Ambulance Stroke Trial - TSC) trial for Stroke in USA in early 2019
  • 10 Jul 2018 Diffusion Pharmaceuticals has patent protection for oral formulations of trans-carotenoids in USA
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