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Trans-sodium crocetinate - Diffusion Pharmaceuticals

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Drug Profile

Trans-sodium crocetinate - Diffusion Pharmaceuticals

Alternative Names: Crocetin sodium salt; Sodium crocetinate; Trans sodium crocetinate; Transcrocetinate sodium; TSC; TSC-cpd

Latest Information Update: 21 Nov 2019

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At a glance

  • Originator Office of Naval Research; University of Virginia
  • Developer Diffusion Pharmaceuticals
  • Class Antineoplastics; Carotenoids; Neuroprotectants; Radiation-sensitising agents; Small molecules; Vascular disorder therapies
  • Mechanism of Action Oxygen compound modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Brain metastases; Glioblastoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Glioblastoma
  • Phase II Stroke
  • Preclinical Brain metastases; Pancreatic cancer
  • Discontinued Peripheral arterial disorders

Most Recent Events

  • 11 Nov 2019 The Data Safety Monitoring Board recommends continuation of the INTACT trial using 1.5 mg/kg of Trans-sodium crocetinate
  • 22 Aug 2019 Phase-II clinical trials in Stroke in USA (IV) (NCT03763929)
  • 11 Feb 2019 Diffusion Pharmaceuticals, in collaboration with the University of California Los Angeles and the University of Virginia, plans a phase II PHAST-TSC (Pre-Hospital Ambulance Stroke Trial - TSC) trial for Stroke in USA in the second quarter of 2019
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