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Avacincaptad pegol - IVERIC bio

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Drug Profile

Avacincaptad pegol - IVERIC bio

Alternative Names: Anti-C5 aptamer; ARC-1905; ASP-3021; Avacincaptad pegol sodium; IZERVAY; Zimura

Latest Information Update: 24 Nov 2025

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At a glance

  • Originator Archemix Corporation
  • Developer IVERIC bio
  • Class Eye disorder therapies; Oligonucleotides; Polyethylene glycols
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Dry age-related macular degeneration
  • Phase II Polypoidal choroidal vasculopathy; Wet age-related macular degeneration
  • Discontinued Stargardt disease

Most Recent Events

  • 30 Oct 2025 Discontinued - Phase-II for Stargardt disease in USA, Hungary, France, Germany, Italy, Israel, United Kingdom, Spain due to lack of efficacy (Intravitreous) (Astellas pipeline, November 2025)
  • 30 Oct 2025 Discontinued - Phase-III for Stargardt disease due to lack of efficacy (Intravitreous) (Astellas pipeline, November 2025)
  • 19 Oct 2025 Efficacy and adverse events data from the phase III GATHER2 OLE trial in Dry age-related macular degeneration released by Astellas Pharma

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