Tucatinib - Array BioPharma/Cascadian Therapeutics

Drug Profile

Tucatinib - Array BioPharma/Cascadian Therapeutics

Alternative Names: ARRY-380; Irbinitinib; ONT-380

Latest Information Update: 13 Mar 2018

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At a glance

  • Originator Array BioPharma
  • Developer Array BioPharma; Cascadian Therapeutics; Dana-Farber Cancer Institute
  • Class 2 ring heterocyclic compounds; Antineoplastics; Diamines; Furans; Pyridines; Quinazolinones; Small molecules; Triazoles
  • Mechanism of Action ERBB 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Colorectal cancer; Breast cancer; Brain metastases
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Breast cancer; Colorectal cancer
  • No development reported Solid tumours

Most Recent Events

  • 09 Mar 2018 Cascadian Therapeutics has been acquired by Seattle Genetics
  • 07 Feb 2018 Cascadian Therapeutics initiates an expanded-access programme for Breast Cancer in USA (NCT03424473)
  • 04 Jan 2018 Tucatinib - Array BioPharma/Cascadian Therapeutics is available for licensing in Europe, Asia (excluding USA) as of 04 Jan 2018. http://www.cascadianrx.com/
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