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Tucatinib - Array BioPharma/Seagen

Drug Profile

Tucatinib - Array BioPharma/Seagen

Alternative Names: ARRY 380; Irbinitinib; MK 7119; ONT 380; TUKYSA

Latest Information Update: 24 May 2024

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At a glance

  • Originator Array BioPharma
  • Developer Array BioPharma; Criterium; Merck & Co; Merck Sharp & Dohme; Novartis; Seagen
  • Class 2 ring heterocyclic compounds; Antineoplastics; Diamines; Oxazoles; Pyridines; Quinazolines; Small molecules; Triazoles
  • Mechanism of Action ERBB 2 receptor antagonists; Phosphorylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Colorectal cancer; Breast cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; HER2 positive breast cancer
  • Phase II/III Gastrointestinal cancer
  • Phase II Biliary cancer; Bladder cancer; Cervical cancer; Endometrial cancer; Gastric cancer; Non-small cell lung cancer; Solid tumours; Urogenital cancer
  • Phase I/II Cholangiocarcinoma; Gallbladder cancer

Most Recent Events

  • 27 Mar 2024 Pharmacodynamics data from a phase-II/III MOUNTAINEER-02 trials in Gastrointestinal cancer presented at the 125th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT-2024)
  • 12 Feb 2024 Phase-II clinical trials in Urogenital cancer (Second-line therapy or greater, Metastatic disease) (PO), prior to February 2024 (Pfizer pipeline, February 2024)
  • 07 Feb 2024 Seagen initiates a phase Ib/II trial for Solid tumours (Late-stage disease, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA(PO) (NCT06157892)
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