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Selexipag - Actelion/Nippon Shinyaku

Drug Profile

Selexipag - Actelion/Nippon Shinyaku

Alternative Names: ACT-293987; JNJ-678896049; NS-304; Uptravi

Latest Information Update: 15 Mar 2024

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At a glance

  • Originator Nippon Shinyaku
  • Developer Actelion Pharmaceuticals; Nippon Shinyaku
  • Class Acetamides; Amines; Anti-inflammatories; Antithrombotics; Pyrazines; Small molecules; Sulfonamides; Vascular disorder therapies; Vasodilators
  • Mechanism of Action Epoprostenol receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary hypertension; Pulmonary arterial hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pulmonary arterial hypertension; Pulmonary hypertension
  • Phase III Arteriosclerosis obliterans
  • Clinical Phase Unknown Thromboangiitis obliterans
  • No development reported Raynaud's disease
  • Discontinued Spinal stenosis

Most Recent Events

  • 29 Feb 2024 Actelion terminates a phase II/III trial for Pulmonary arterial hypertension in USA, UK, Netherlands, Hungary, Germany, Poland, Spain, Brazil, Belgium, Canada, France and Italy due to the lower-than-expected recruitment rate (NCT03942211) (EudraCT2018-004887-74)
  • 19 May 2023 Pooled efficacy data from the phase III GRIPHON, SERAPHIN and COMPASS-2 trials in Pulmonary arterial hypertension presented at the 119th International Conference of the American Thoracic Society (ATS-2023)
  • 28 Feb 2023 No recent reports of development identified for phase-I development in Pulmonary-arterial-hypertension(In volunteers) in Belgium (PO, Controlled release)
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