Ramucirumab - Eli Lilly

Drug Profile

Ramucirumab - Eli Lilly

Alternative Names: Anti-flk-1 monoclonal antibody - ImClone; Anti-KDR monoclonal antibody - ImClone; Anti-VEGFR 2 monoclonal antibody - ImClone; Cyramza; IMC-1121; IMC-1121-B; IMC-1C11 - ImClone; LY-3009806; Ramcilumab; ramsilmab; Ramsilomab; Ramsylmab; Ramsylumab; Sairamza; Silamza

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Dyax
  • Developer AstraZeneca; Dana-Farber Cancer Institute; Eli Lilly; Merck Sharp & Dohme; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma; Gastric cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Gastric cancer; Non-small cell lung cancer
  • Phase III Hepatocellular carcinoma; Oesophageal cancer; Urogenital cancer
  • Phase II Biliary cancer; Carcinoid tumour; Solid tumours
  • No development reported Breast cancer; Malignant melanoma; Ovarian cancer; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 04 Apr 2018 Eli Lilly intends to initiate regulatory submissions for Hepatocellular carcinoma in mid-2018
  • 05 Feb 2018 Eli Lilly initiates enrolment in a phase II trial for Non small-cell lung cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Japan (UMIN000030598)
  • 01 Feb 2018 Eli Lilly completes a phase II trial for Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (IV) (NCT01634555)
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